Journal article
The contribution of sensory system functional connectivity reduction to clinical pain in fibromyalgia
J Pujol, D Macià, A Garcia-Fontanals, L Blanco-Hinojo, M López-Solà, S Garcia-Blanco, V Poca-Dias, BJ Harrison, O Contreras-Rodríguez, J Monfort, F Garcia-Fructuoso, J Deus
Pain | ELSEVIER SCIENCE BV | Published : 2014
Abstract
Fibromyalgia typically presents with spontaneous body pain with no apparent cause and is considered pathophysiologically to be a functional disorder of somatosensory processing. We have investigated potential associations between the degree of self-reported clinical pain and resting-state brain functional connectivity at different levels of putative somatosensory integration. Resting-state functional magnetic resonance imaging was obtained in 40 women with fibromyalgia and 36 control subjects. A combination of functional connectivity-based measurements were used to assess (1) the basic pain signal modulation system at the level of the periaqueductal gray (PAG); (2) the sensory cortex with an..
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Grants
Awarded by Ministerio de Ciencia, Innovación y Universidades
Funding Acknowledgements
This study was supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434). The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Groups SGR 2009/718, 1435 and 1450. Ms. Blanco-Hinojo is supported by the PFIS Grant FI10/00387 from the Carlos III Health Institute. Dr. Lopez-Sola is supported by the FPU Grant AP2005-0408 from the Ministry of Education of Spain. Dr. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (I.D. 628509).